"Learn how to identify gluten sensitivity and strengthen your gut, so it may become less sensitive."
-Dr. Louis Granirer
Gluten Intolerance Remedy in Manhattan, New York City
Non celiac gluten intolerance is a serious problem igniting chronic inflammation in the body. The inflammation is caused by the immune system attacking the gluten. Basically, the immune system produces antibodies to the gluten. It sees the gluten as a bacteria, virus, or unwelcomed addition to the body and goes into a frenzy to eradicate it. Each time the body encounters gluten (which could be several times per day in the standard American diet) the immune system is fired up. This produces chronic inflammation which leads to chronic disease processes and a whole host of symptoms.
Gluten prompts the body to release a substance called zonulin, which regulates the permeability of the intestines. Intestinal-lining cells are pried apart by zonulin. Undigested food particles can enter the blood stream. The immune system reacts by releasing inflammatory substances. This is referred to as "leaky gut syndrome". Since, impermeability is decreased; minerals, essential vitamins, and necessary nutrients are not readily absorbed. This leads to underlying nutritional deficiencies. You may think you are eating and reaping the benefits of eating healthy foods, but the body is not absorbing as much of the nutrients as you think.
Another theory and proposed mechanism of how gluten can affect various organ systems involves peptidase enzyme called DPP4. If there is a failure or insufficiency of DPP4, the body can't efficiently breakdown the proteins in gluten. The immune system can be fooled by molecular mimicry as the undigested protein fragment can be mistaken for a virus. As a result of this, antibodies are aimed at the protein and can cause damage to tissues in an auto-immune reaction.
Symptoms of Gluten Intolerance and Celiac Disease
The symptoms that non-celiac gluten intolerance can incite can range from joint pain, anxiety, depression, headaches, fatigue, cramping, stomach pain, indigestion, body aches, rashes, acid reflux, thyroid disorders, infertility, etc. As you can see these symptoms are so vast and can be related to multiple diseases.
This is where the problem lies in the medical community recognizing this sensitivity as a dire health problem. Since, medicine is primarily focused on symptom relief; the majority of therapies for these symptoms are focused on pharmacology and not possible nutritional causative factors.